Article

1-deoxysphingolipid biosynthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells

2022-01-22

Abstract excerpt

<h4>ABSTRACT</h4> Serine palmitoyltransferase (SPT) predominantly incorporates serine and fatty acyl-CoAs into diverse sphingolipids that serve as structural components of membranes and signaling molecules within or amongst cells. However, SPT also uses alanine as a substrate in the contexts of low serine availability, alanine accumulation, or disease-causing mutations in hereditary sensory neuropathy type I (HSA...

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Literature Corpus work: 42b1c439-20a4-589f-b2c5-9cfc4b3ffca4
DOI: 10.1101/2022.01.19.476986

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