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Article

Targeting distinct amino acid metabolic vulnerabilities in IDH-mutant and IDH-wildtype gliomas.

Acta neuropathologica communications - 29 Nov 2025

Ohba Shigeo, Hirayama Akiyoshi, Teranishi Takao, Hitachi Keisuke, Yamaguchi Hisateru, Murayama Kazuhiro, Natsumeda Manabu, Tateishi Kensuke, Tsuchida Kunihiro, Wakimoto Hiroaki, Saya Hideyuki, Pieper Russell, Hirose Yuichi

Abstract excerpt

Lower grade gliomas frequently harbor mutations in isocitrate dehydrogenase (IDH), which define biologically distinct tumor subtypes. Although IDH-mutant and IDH-wildtype gliomas share similar histological morphology, they display markedly different metabolic profiles that may be exploited for targeted therapy. In this study, we investigated therapeutic approaches tailored to these metabolic differences. Using...

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Identifiers

PMID: 41318461
DOI: 10.1186/s40478-025-02193-8
PMCID: PMC12772011

Genes

GLUD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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