Article
IDH1 mutations induce organelle defects via dysregulated phospholipids.
Nature communications - 27 Jan 2021
Lita Adrian, Pliss Artem, Kuzmin Andrey, Yamasaki Tomohiro, Zhang Lumin, Dowdy Tyrone, Burks Christina, de Val Natalia, Celiku Orieta, Ruiz-Rodado Victor, Nicoli Elena-Raluca, Kruhlak Michael, Andresson Thorkell, Das Sudipto, Yang Chunzhang, Schmitt Rebecca, Herold-Mende Christel, Gilbert Mark R, Prasad Paras N, Larion Mioara
Abstract excerpt
Infiltrating gliomas are devastating and incurable tumors. Amongst all gliomas, those harboring a mutation in isocitrate dehydrogenase 1 mutation (IDH1mut) acquire a different tumor biology and clinical manifestation from those that are IDH1WT. Understanding the unique metabolic profile reprogrammed by IDH1 mutation has the potential to identify new molecular targets for glioma therapy. Herein, we uncover...
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