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Article

Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming.

Molecular cell - 26 Dec 2013

Payer Bernhard, Rosenberg Michael, Yamaji Masashi, Yabuta Yukihiro, Koyanagi-Aoi Michiyo, Hayashi Katsuhiko, Yamanaka Shinya, Saitou Mitinori, Lee Jeannie T

Abstract excerpt

Transitions between pluripotent and differentiated states are marked by dramatic epigenetic changes. Cellular differentiation is tightly linked to X chromosome inactivation (XCI), whereas reprogramming to induced pluripotent stem cells (iPSCs) is associated with X chromosome reactivation (XCR). XCR reverses the silent state of the inactive X, occurring in mouse blastocysts and germ cells. In spite of its...

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Source

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Identifiers

PMID: 24268575
DOI: 10.1016/j.molcel.2013.10.023
PMCID: PMC3950835

Genes

PRDM14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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