Article

Hepatocyte and adipocyte CDO1-mediated intracellular cysteine catabolism differentially modulates diet-induced obesity and fatty liver in mice

2025-12-09

Abstract excerpt

<h4>Background and Aims</h4> Plasma cysteine has been positively linked to BMI in humans. Consistently, dietary cysteine restriction significantly decreases obesity in mice via mechanisms that are incompletely defined. Cysteine dioxygenase type 1 (CDO1) mediates the major cysteine catabolism pathway and is highly expressed in hepatocytes and adipocytes. The goal of this study is to determine the impact of this en...

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Literature Corpus work: 3a271722-b6f9-5fe1-846f-49665c3d5ea0
DOI: 10.64898/2025.12.05.692669

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