Article

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis

2025-03-01

Abstract excerpt

Metabolic dysfunction-associated steatohepatitis (MASH) represents a progressive form of steatotic liver disease which increases the risk for fibrosis and advanced liver disease. The accumulation of discrete species of bioactive lipids has been postulated to activate signaling pathways that promote inflammation and fibrosis. However, the key pathogenic lipid species is a matter of debate. We explored candidates us...

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Literature Corpus work: 6d0b1199-1190-562e-9b95-79082ce54ec5
DOI: 10.1101/2025.02.25.640203

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