Article
Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.
Annals of the New York Academy of Sciences - 1 Jan 2016
Niewiadomski Julie, Zhou James Q, Roman Heather B, Liu Xiaojing, Hirschberger Lawrence L, Locasale Jason W, Stipanuk Martha H
Abstract excerpt
To gain further insights into the effects of elevated cysteine levels on energy metabolism and the possible mechanisms underlying these effects, we conducted studies in cysteine dioxygenase (Cdo1)-null mice. Cysteine dioxygenase (CDO) catalyzes the first step of the major pathway for cysteine catabolism. When CDO is absent, tissue and plasma cysteine levels are elevated, resulting in enhanced flux of cysteine...
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