Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles.

PloS one - 1 Jan 2016

Elshorbagy Amany K, Jernerén Fredrik, Scudamore Cheryl L, McMurray Fiona, Cater Heather, Hough Tertius, Cox Roger, Refsum Helga

Abstract excerpt

BACKGROUND: Although reduced glutathione (rGSH) is decreased in obese mice and humans, block of GSH synthesis by buthionine sulfoximine (BSO) results in a lean, insulin-sensitive phenotype. Data is lacking about the effect of BSO on GSH precursors, cysteine and glutamate. Plasma total cysteine (tCys) is positively associated with stearoyl-coenzyme A desaturase (SCD) activity and adiposity in humans and animal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Body Composition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eating

Share to Energy Metabolism

Share to Fatty Acids

Share to Glutathione

Share to Locomotion

Share to Sulfhydryl Compounds

Source

Open in PubMed Open full text

Identifiers

PMID: 27788147
DOI: 10.1371/journal.pone.0163214
PMCID: PMC5082875

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles.PMID 27788147Read ↗

Pharmacological recapitulation of the lean phenotype induced by the lifespan-extending sulfur amino acid-restricted diet.Semantic proximity Read ↗

Hepatocyte and adipocyte CDO1-mediated intracellular cysteine catabolism differentially modulates diet-induced obesity and fatty liver in miceSemantic proximity Read ↗

Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.Semantic proximity Read ↗

A high-fat diet differentially regulates glutathione phenotypes in the obesity-prone mouse strains DBA/2J, C57BL/6J, and AKR/J.Semantic proximity Read ↗

Deciphering pathophysiological mechanisms underlying cystathionine beta-synthase-deficient homocystinuria using targeted metabolomics, liver proteomics, sphingolipidomics and analysis of mitochondrial functionSemantic proximity Read ↗

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in miceSemantic proximity Read ↗

Inhibition of systemic mammalian metabolism by carnitine mimics from the gut microbiotaSemantic proximity Read ↗

Regulation of odd chain fatty acid metabolism in the development of metabolic diseases in mice fed a low protein dietSemantic proximity Read ↗

Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trialSemantic proximity Read ↗

Dietary methionine/choline deficiency affects behavioural and molecular circadian rhythmsSemantic proximity Read ↗

Urinary Signatures Predict Calorie Restriction-Mediated Weight Loss in Obese Diversity Outbred MiceSemantic proximity Read ↗

Protein restriction and branched‐chain amino acid restriction promote geroprotective shifts in metabolismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.