Article

Hepatic stellate cells-specific Loxl1 deficiency abrogates hepatic inflammation, fibrosis, and corrects lipid metabolic abnormalities in non-obese NASH mice

2021-03-03

Abstract excerpt

<title>Abstract</title> <bold>Background & Aims:</bold> Lysyl oxidase-like-1 (LOXL1), a vital crosslinking enzyme in extracellular matrix (ECM) protein maintenance, is well established in fibrosis via mediating ECM stabilization. However, the potential role of LOXL1 in the pathogenesis of nonalcoholic steatohepatitis (NASH) has not been previously studied.<bold>Methods: </bold>We generated Loxl1fl/fl</sup...

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Literature Corpus work: 542e1302-6d19-5baf-9672-6f6a2107d22a
DOI: 10.21203/rs.3.rs-260786/v1

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