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Article

Pharmacological recapitulation of the lean phenotype induced by the lifespan-extending sulfur amino acid-restricted diet.

Aging - 7 Apr 2025

Ommi Naidu B, Mattocks Dwight A L, Kalecký Karel, Bottiglieri Teodoro, Nichenametla Sailendra N

Abstract excerpt

Sulfur amino acid restriction (SAAR), lowering the dietary concentration of sulfur amino acids methionine and cysteine, induces strong anti-obesity effects in rodents. Due to difficulties in formulating the SAAR diet for human consumption, its translation is challenging. Since our previous studies suggest a mechanistic role for low glutathione (GSH) in SAAR-induced anti-obesity effects, we investigated if the...

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Identifiers

PMID: 40202448
DOI: 10.18632/aging.206237
PMCID: PMC12074818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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