Article

The role of intestine in metabolic dysregulation in murine Wilson disease

2023-01-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and aims</h4> Major clinical manifestations of Wilson disease (WD) are related to copper accumulation in the liver and the brain, and little is known about other tissues involvement in metabolic changes in WD. In vitro studies suggested that the loss of intestinal ATP7B could contribute to metabolic dysregulation in WD. We tested this hypothesis by evaluating gut microbiota and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de159384-3a40-5d8b-9dd1-e323396745f4
DOI: 10.1101/2023.01.13.524009

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The role of intestine in metabolic dysregulation in murine Wilson diseaseDOI 10.1101/2023.01.13.524009Read

Systemic deletion of Atp7b modifies the hepatocytes' response to copper overload in the mouse models of Wilson disease.Semantic proximity Read

Hepatic Steatosis in the Mouse Model of Wilson Disease Coincides with a Muted Inflammatory Response.Semantic proximity Read

Modifying factors and phenotypic diversity in Wilson's disease.Semantic proximity Read

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes.Semantic proximity Read

High-Calorie Diet Accelerates the Liver Tissue Degeneration and Induces Subcutaneous White-to-Brown Fat Conversion in Mice with a Single-Allele Atp7b Mutation.Semantic proximity Read

Wilson disease: intersecting DNA methylation and histone acetylation regulation of gene expression in a mouse model of hepatic copper accumulationSemantic proximity Read

Non-coding RNAs in Wilson's Disease: Plausible drivers of hepatic symptom heterogeneity.Semantic proximity Read

Wilson Disease: Update on Pathophysiology and TreatmentSemantic proximity Read

<i>Atp7b</i> −/− mice as a model for studies of Wilson's diseaseSemantic proximity Read

Wilson Disease: Intersecting DNA Methylation and Histone Acetylation Regulation of Gene Expression in a Mouse Model of Hepatic Copper Accumulation.Semantic proximity Read

Metabolomic profiling of Wilson disease, an inherited disorder of copper metabolism, and diseases with similar symptoms but normal copper metabolismSemantic proximity Read

Mechanistic basis for protection against fatty liver disease by <i>CIDEB</i> loss-of-function mutationsSemantic proximity Read