Article

Mechanistic basis for protection against fatty liver disease by <i>CIDEB</i> loss-of-function mutations

2025-04-06

Abstract excerpt

<h4>Background & Aims</h4> Somatic and germline CIDEB mutations are associated with protection from chronic liver diseases. The mechanistic basis and whether CIDEB suppression would be an effective therapy against fatty liver disease remain unclear. <h4>Methods</h4> 21 CIDEB somatic mutations were introduced into cells to assess functionality. In vivo screening was used to trace Cideb mutant clones in mice...

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Literature Corpus work: c24bc300-865a-5341-935b-af944de8f987
DOI: 10.1101/2025.04.01.646492

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