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Liver specific transgenic expression of CYP7B1 attenuates early western diet-induced MASLD progression

12 Feb 2025

Abstract excerpt

Effect of liver specific oxysterol 7α-hydroxylase (CYP7B1) overexpression on the Western diet (WD)-induced metabolic dysfunction-associated steatotic liver disease (MASLD) progression was studied in mice. Among various hepatic genes impacted during MASLD development, CYP7B1 is consistently suppressed in multiple MASLD mouse models and in human MASLD cohorts. CYP7B1 enzyme suppression leads to accumulations of...

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PMID: 39952566
DOI: 10.1016/j.jlr.2025.100757

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