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Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.

Diabetologia - 1 Dec 2016

Merry Troy L, Tran Melanie, Dodd Garron T, Mangiafico Salvatore P, Wiede Florian, Kaur Supreet, McLean Catriona L, Andrikopoulos Sofianos, Tiganis Tony

Abstract excerpt

AIMS/HYPOTHESIS: In obesity oxidative stress is thought to contribute to the development of insulin resistance, non-alcoholic fatty liver disease and the progression to non-alcoholic steatohepatitis. Our aim was to examine the precise contributions of hepatocyte-derived H2O2 to liver pathophysiology. METHODS: Glutathione peroxidase (GPX) 1 is an antioxidant enzyme that is abundant in the liver and converts H2O2...

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PMID: 27628106
DOI: 10.1007/s00125-016-4084-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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