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Article

Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice

28 May 2016

Abstract excerpt

Aging increases the risk of type 2 diabetes, and this can be prevented by dietary restriction (DR). We have previously shown that DR inhibits the downregulation of miRNAs and their processing enzymes - mainly Dicer - that occurs with aging in mouse white adipose tissue (WAT). Here we used fat-specific Dicer knockout mice (AdicerKO) to understand the contributions of adipose tissue Dicer to the metabolic effects...

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PMID: 27241713
DOI: 10.18632/aging.100970

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