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GWAS and functional studies implicate a role for altered DNA repair in the evolution of drug resistance in Mycobacterium tuberculosis

2022-01-04

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The emergence of drug resistance in Mycobacterium tuberculosis ( Mtb ) is alarming and demands in-depth knowledge for timely diagnosis. We performed genome-wide association analysis (GWAS) using 2237 clinical strains of Mtb to identify novel genetic factors that evoke drug resistance. In addition to the known direct targets, for the first time, we identified a strong association between the mutations in the DNA...

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Literature Corpus work: 3a26acf8-407d-50ed-a1ee-cad1b0fdcda3
DOI: 10.1101/2022.01.04.474954

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GWAS and functional studies implicate a role for altered DNA repair in the evolution of drug resistance in <i>Mycobacterium tuberculosis</i>

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