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Article

GWAS and functional studies suggest a role for altered DNA repair in the evolution of drug resistance in Mycobacterium tuberculosis.

eLife - 25 Jan 2023

Naz Saba, Paritosh Kumar, Sanyal Priyadarshini, Khan Sidra, Singh Yogendra, Varshney Umesh, Nandicoori Vinay Kumar

Abstract excerpt

The emergence of drug resistance in Mycobacterium tuberculosis (Mtb) is alarming and demands in-depth knowledge for timely diagnosis. We performed genome-wide association analysis using 2237 clinical strains of Mtb to identify novel genetic factors that evoke drug resistance. In addition to the known direct targets, we identified for the first time, a strong association between mutations in DNA repair genes and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36695572
DOI: 10.7554/eLife.75860
PMCID: PMC9876569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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