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A clinical mutation in <i>uvrA</i> , a DNA repair gene, confers survival advantage to <i>Mycobacterium tuberculosis</i> in the host

2024-10-07

Abstract excerpt

DNA repair pathways play an essential role in maintaining the genomic integrity of bacteria, and a perturbation in their biological activity helps bacteria survive under duress. In drug-resistant clinical strains, we identified a Q135K mutation in the uvrA gene, a DNA repair pathway gene. To delineate the role of uvrA and the Q135K mutation, we generated the gene replacement mutant of UvrA ( RvΔuvrA ) in Mycob...

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Literature Corpus work
84b7fe1d-51af-5ced-843e-492c9e645662
DOI
10.1101/2024.10.07.616951
Open publication

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A clinical mutation in <i>uvrA</i> , a DNA repair gene, confers survival advantage to <i>Mycobacterium tuberculosis</i> in the hostDOI 10.1101/2024.10.07.616951
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