Article

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution

2025-11-27

Abstract excerpt

The rapid emergence of multidrug-resistant Mycobacterium tuberculosis (Mtb) threatens global TB control, yet the mechanisms enabling rapid evolution of drug resistance in Mtb remain poorly understood. Here we reveal that pre-existing mutations in oxidative stress response genes create permissive genomic backgrounds that accelerate high-level isoniazid resistance (INH R ) without fitness costs, challenging the pa...

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Literature Corpus work: 05675f12-c562-5f99-942e-dff142d68316
DOI: 10.1101/2025.11.19.689367

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