Article

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution

2025-12-04

Abstract excerpt

<title>Abstract</title> <p> The rapid emergence of multidrug-resistant <italic>Mycobacterium tuberculosis</italic> (Mtb) threatens global TB control, yet the mechanisms enabling rapid evolution of drug resistance in Mtb remain poorly understood. Here we reveal that pre-existing mutations in oxidative stress response genes create permissive genomic backgrounds that accelerate high-level isoniazid resistance (IN...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd6d2c39-98c6-56db-94ef-be849dbf6a3a
DOI: 10.21203/rs.3.rs-8167376/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolutionDOI 10.21203/rs.3.rs-8167376/v1Read

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolutionSemantic proximity Read

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution.Semantic proximity Read

Rifampicin exposure reveals within-host <i>Mycobacterium tuberculosis</i> diversity in patients with delayed culture conversionSemantic proximity Read

Rifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion.Semantic proximity Read

Evolutionary dynamics of drug resistance in MDR-TB: Heterogeneous minor variants and extensive compensatory mutations.Semantic proximity Read

Desiccation-induced DNA damage facilitates drug resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

GWAS and functional studies implicate a role for altered DNA repair in the evolution of drug resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Signatures of selection at drug resistance loci in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Genome scale CRISPRi reveals both shared and strain-specific vulnerabilities in genetically diverse drug-resistant strains of Mycobacterium tuberculosis.Semantic proximity Read

<i>In host</i> mutational adaptation of <i>Mycobacterium tuberculosis</i> complex strainsSemantic proximity Read

Resistance at No Cost: The Transmissibility and Potential for Disease Progression of Drug-Resistant <i>M. Tuberculosis</i>Semantic proximity Read

KatG inactivation generates vulnerabilities in isoniazid resistant strains of <i>Mycobacterium tuberculosis</i>Semantic proximity Read