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Genome wide analyses reveal the role of mutator phenotypes in the emergence of drug resistance in <i>Mycobacterium tuberculosis</i>

2025-01-22

Abstract excerpt

Antimicrobial combination therapy is widely used to combat Mycobacterium tuberculosis ( Mtb ), yet resistance rates continue to rise. Mutator strains, with defects in DNA repair genes, are a known source of resistance in other bacterial infections, but their global role in Mtb remains unclear. Here, we provide a comprehensive overview of the contribution of single nucleotide polymorphisms (SNPs) in DNA Repair,...

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Literature Corpus work
d9d0177a-e76e-5043-89a0-94ba325f96fc
DOI
10.1101/2025.01.17.633521
Open publication

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Genome wide analyses reveal the role of mutator phenotypes in the emergence of drug resistance in <i>Mycobacterium tuberculosis</i>DOI 10.1101/2025.01.17.633521
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