Article
Genome scale CRISPRi reveals both shared and strain-specific vulnerabilities in genetically diverse drug-resistant strains of Mycobacterium tuberculosis.
Nature communications - 5 Jun 2026
Wang XinYue, Jowsey William J, Cheung Chen-Yi, Dickerhof Nina, Chapman Cassandra L, Taka Jamie R H, Hampton Mark B, Bashiri Ghader, Gardner Paul P, Fineran Peter C, Cook Gregory M, Jackson Simon A, McNeil Matthew B
Abstract excerpt
The global health burden caused by Mycobacterium tuberculosis is aggravated by the emergence and spread of drug resistance. Mutations that cause drug resistance can have collateral effects that increase the vulnerability of downstream pathways to inhibition. Here, using genome scale CRISPR interference we identified collateral effects associated with different drug-resistant genotypes of M. tuberculosis. We...
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