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Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis

3 Aug 2020

Abstract excerpt

survives during antibiotic treatment is necessary to rationally devise more effective tuberculosis (TB) chemotherapy regimens. Using genome-wide mutant fitness profiling and the mouse model of TB, we identified genes that alter antibiotic efficacy specifically in the infection environment and associated several of these genes with natural genetic variants found in drug-resistant clinical isolates. These data...

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PMID: 32753506
DOI: 10.1128/msystems.00396-20

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