Article

Multiomic profiling reveals aberrant immunomodulatory signature in β-propeller protein-associated neurodegeneration patient iPSC-derived microglia

2025-09-04

Abstract excerpt

Microglia are the primary immune cells of the central nervous system and play a crucial role in maintaining brain homeostasis. In common neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease (PD), early and sustained microglial activation has been shown to precede neuronal loss, with elevated levels of microglia-derived inflammatory mediators detected in affected brain regions. In contrast...

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Literature Corpus work: a29fca74-651f-558b-98d7-03def7bd15c6
DOI: 10.1101/2025.09.04.668126

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