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Article

Aberrant immunomodulatory signature in β-propeller protein-associated neurodegeneration patient iPSC-derived microglia.

Scientific reports - 15 Jun 2026

Özata Gamze, Wise Rachel M, Cardona-Alberich Aida, Mayeen Naiyareen F, Müller Stephan A, Lichtenthaler Stefan F, Zecca Luigi, Burbulla Lena F

Abstract excerpt

Microglia are the brain's resident immune cells, essential for homeostasis and implicated in common neurodegenerative diseases like Alzheimer's and Parkinson's disease (PD), where their early activation and sustained inflammatory mediator release contribute to neuronal loss. However, their role in rare disorders is unclear. β-propeller protein-associated neurodegeneration (BPAN), caused by WDR45 mutations, shares...

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PMID: 42297977
DOI: 10.1038/s41598-026-55648-w
PMCID: PMC13270018

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