Article

Protein folding stress shapes microglial phenotype in progressive supranuclear palsy

2026-01-28

Abstract excerpt

<h4>SUMMARY</h4> Microglia play a pivotal role in neurodegeneration, yet their response to tau pathology remains incompletely understood. Through single-nucleus RNA sequencing of Aβ plaque–free frontal cortex from 4R tauopathy progressive supranuclear palsy (PSP) brains, we reveal a distinct transcriptional reprogramming of homeostatic microglia. PSP microglia exhibit pronounced protein-folding and ER-stress sign...

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Literature Corpus work: 61dd51c0-bf42-503b-b923-e0d2af5885ed
DOI: 10.64898/2026.01.26.700084

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