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Article

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.

Journal of cell science - 15 Jul 2009

Seaman Matthew N J, Harbour Michael E, Tattersall Daniel, Read Eliot, Bright Nicholas

Abstract excerpt

Retromer is a membrane-associated heteropentameric coat complex that functions in the endosome-to-Golgi retrieval of the cation-independent mannose-6-phosphate receptor, the Wntless protein and other membrane proteins of physiological significance. Retromer comprises two functional subcomplexes: the cargo-selective subcomplex is a trimer of the VPS35, VPS29, VPS26 proteins, whereas the sorting nexin proteins,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19531583
DOI: 10.1242/jcs.048686
PMCID: PMC2704877

Genes

VPS35
VPS29

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.PMID 19531583Read ↗

A mechanism for retromer endosomal coat complex assembly with cargo.Semantic proximity Read ↗

EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval.Semantic proximity Read ↗

Architecture and mechanism of metazoan retromer:SNX3 tubular coat assemblySemantic proximity Read ↗

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics.Semantic proximity Read ↗

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complexSemantic proximity Read ↗

Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through auto-inhibitionSemantic proximity Read ↗

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Inhibition of late endosomal maturation restores Wnt secretion in Caenorhabditis elegans vps-29 retromer mutants.Semantic proximity Read ↗

Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval.Semantic proximity Read ↗

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.Semantic proximity Read ↗

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein AggregationSemantic proximity Read ↗

<p class="MDPI13authornames">EhVps29 Has a Role in the Location of the Retromer Complex and the Function of Key Virulence Factors in <em>Entamoeba histolytica</em>Semantic proximity Read ↗

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