Article

Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase

2022-03-31

Abstract excerpt

The enteropeptidase (EP) initiates the intestinal digestion by proteolytic processing of trypsinogen, generating catalytic active trypsin. The dysfunction of EP will cause a series of pancreatic diseases, the most severe of which is acute necrotizing pancreatitis. However, the molecular mechanism of EP activation and substrate recognition remain elusive due to the lack of structural information, hampering the stru...

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Literature Corpus work: 39f40d4d-a363-53ac-8949-c701f8884e8a
DOI: 10.21203/rs.3.rs-1468072/v1

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