Article

Structure of Dimeric Lipoprotein Lipase Reveals a Pore for Hydrolysis of Acyl Chains

2023-03-22

Abstract excerpt

Lipoprotein lipase (LPL) hydrolyzes triglycerides from circulating lipoproteins, releasing free fatty acids. Active LPL is needed to prevent hypertriglyceridemia, which is a risk factor for cardiovascular disease (CVD). Using cryogenic electron microscopy (cryoEM), we determined the structure of an active LPL dimer at 3.9 Å resolution. This is the first structure of a mammalian lipase with an open, hydrophobic por...

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Literature Corpus work: a20a9525-a914-5edd-baf9-448af65a13c0
DOI: 10.1101/2023.03.21.533650

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