Protease propeptide structures, mechanisms of activation, and functions.

Abstract excerpt

Proteases are a diverse group of hydrolytic enzymes, ranging from single-domain catalytic molecules to sophisticated multi-functional macromolecules. Human proteases are divided into five mechanistic classes: aspartate, cysteine, metallo, serine and threonine proteases, based on the catalytic mechanism of hydrolysis. As a protective mechanism against uncontrolled proteolysis, proteases are often produced and...

Topics

• Amino Acid Sequence
• Biomarkers
• Catalytic Domain
• Enzyme Activation
• Enzyme Precursors
• Humans
• Mutation