Article

Structure of the Human Signal Peptidase Complex Reveals the Determinants for Signal Peptide Cleavage

2020-11-11

Abstract excerpt

The signal peptidase complex (SPC) is an essential membrane complex in the endoplasmic reticulum (ER), where it removes signal peptides (SPs) from a large variety of secretory pre-proteins with exquisite specificity. Although the determinants of this process have been established empirically, the molecular details of SP recognition and removal remain elusive. Here, we show that the human SPC exists in two function...

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Literature Corpus work: 498a65dd-56f3-5661-818e-ad6e89ac5841
DOI: 10.1101/2020.11.11.378711

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