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Article

Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation.

The Journal of biological chemistry - 5 Apr 2013

Batra Jyotica, Szabó András, Caulfield Thomas R, Soares Alexei S, Sahin-Tóth Miklós, Radisky Evette S

Abstract excerpt

Human chymotrypsin C (CTRC) is a pancreatic serine protease that regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. In cleaving these regulatory sites, which are characterized by multiple flanking acidic residues, CTRC shows substrate specificity that is distinct from that of other isoforms of chymotrypsin and...

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Identifiers

PMID: 23430245
DOI: 10.1074/jbc.M113.457382
PMCID: PMC3617285

Genes

CTRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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