Article

Structural basis for prohibitin-mediated regulation of mitochondrial <i>m</i> -AAA protease

2025-04-15

Abstract excerpt

Mitochondrial function critically dependents on protein quality control systems, with the m -AAA protease plays a key role at the inner mitochondrial membrane (IMM). The evolutionarily conserved prohibitins (PHBs) are essential modulators of this protease across species, yet the molecular mechanisms remain unclear. Here, we present the Cryo-EM structure of the Chaetomium thermophilum PHB ( Ct PHB) complex, rev...

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Literature Corpus work: 1ce4b3d1-734d-5481-a184-fd12018c14d4
DOI: 10.1101/2025.04.15.648916

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