Article

Structures of the Human LONP1 Protease Reveal Regulatory Steps Involved in Protease Activation

2020-11-23

Abstract excerpt

The human mitochondrial AAA+ protein LONP1 is a critical quality control protease involved in regulating diverse aspects of mitochondrial biology including proteostasis, electron transport chain activity, and mitochondrial transcription. As such, genetic or aging-associated imbalances in LONP1 activity are implicated in the pathologic mitochondrial dysfunction associated with numerous human diseases. Despite this...

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Literature Corpus work: 82e356ea-804a-5160-9934-b293784f5e13
DOI: 10.1101/2020.11.23.394858

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