Article

X-ray structures of two active secreted <i>Bacteroides thetaiotaomicron</i> C11 proteases in complex with peptide-based inhibitors

2019-01-17

Abstract excerpt

<h4>ABSTRACT</h4> Commensal bacteria secrete proteins and metabolites to influence host intestinal homeostasis and proteases represent a significant constituent of the components at the host:microbiome interface. Here, we determined the structures of the two secreted C11 cysteine proteases encoded by the established gut commensal Bacteroides thetaiotaomicron. We employed mutational analysis to demonstrate the tw...

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Literature Corpus work: 1ab9a839-def6-5a15-8958-00c957f9bb4a
DOI: 10.1101/522870

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