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Article

Structural insight into the CUB2 domain's role in enteropeptidase-mediated trypsinogen activation.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2026

Song Qiuyue, Peng Lisi, Yang Xiaoli, Xu Jiaheng, Zhang Deyu, Tian Xiaorong, Li Shiyu, Zhang Yang, Ji Baoan, Jin Zhendong, Ding Zhanyu, Li Zhaoshen, Huang Haojie

Abstract excerpt

Elucidating the structure and function of enteropeptidase (EP) is essential for advancing our understanding of its biological significance, particularly in regulating trypsinogen activation. Using cryo-EM and enzymatic activity, we uncovered the significance of the CUB2 domain in mediating the cleavage of macromolecular substrates. We identified crucial binding loops and key residues for EP's proteolytic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41838910
DOI: 10.1073/pnas.2521394123
PMCID: PMC13012022

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