Article

Cryo-EM structures reveal a dynamic transformation process of human alpha-2-macroglobulin working as a protease inhibitor

2022-05-10

Abstract excerpt

Human alpha-2-macroglobulin is a well-known proteases inhibitor against a broad spectrum of proteases. It also plays important roles in immunity, inflammation, and infections. Here, we report cryo-EM structures of human alpha-2-macroglobulin of the native state, the transformed state induced by its authentic substrate, human trypsin, and serial intermediate states between the native and the fully induced state. Th...

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Literature Corpus work: a3f10d26-8204-55cb-9da6-016c998fcbeb
DOI: 10.1101/2022.05.10.491262

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