Article

A domain-swapped proPC1/3 structure reveals a conformational checkpoint for ER export

2026-07-22

Abstract excerpt

Prohormone convertase 1/3 (PC1/3, encoded by PCSK1 ) is a serine protease expressed in neuroendocrine cells that is required to produce insulin, glucagon-like peptide-1, adrenocorticotrophic hormone, and other peptide hormones. PC1/3 is synthesized as the zymogen proPC1/3, which undergoes autocatalytic maturation in the endoplasmic reticulum (ER) before trafficking to secretory granules. However, how autocatalyti...

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Literature Corpus work: a0293cea-50e7-542c-aaa2-5c5a7533c99d
DOI: 10.64898/2026.07.21.739776

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