Article
An atlas of active enhancers across human cell types and tissues.
Nature - 27 Mar 2014
Andersson Robin, Gebhard Claudia, Miguel-Escalada Irene, Hoof Ilka, Bornholdt Jette, Boyd Mette, Chen Yun, Zhao Xiaobei, Schmidl Christian, Suzuki Takahiro, Ntini Evgenia, Arner Erik, Valen Eivind, Li Kang, Schwarzfischer Lucia, Glatz Dagmar, Raithel Johanna, Lilje Berit, Rapin Nicolas, Bagger Frederik Otzen, Jørgensen Mette, Andersen Peter Refsing, Bertin Nicolas, Rackham Owen, Burroughs A Maxwell, Baillie J Kenneth, Ishizu Yuri, Shimizu Yuri, Furuhata Erina, Maeda Shiori, Negishi Yutaka, Mungall Christopher J, Meehan Terrence F, Lassmann Timo, Itoh Masayoshi, Kawaji Hideya, Kondo Naoto, Kawai Jun, Lennartsson Andreas, Daub Carsten O, Heutink Peter, Hume David A, Jensen Torben Heick, Suzuki Harukazu, Hayashizaki Yoshihide, Müller Ferenc, Forrest Alistair R R, Carninci Piero, Rehli Michael, Sandelin Albin
Abstract excerpt
Enhancers control the correct temporal and cell-type-specific activation of gene expression in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial to understand the regulation of differentiation and homeostasis. Here we use the FANTOM5 panel of samples, covering the majority of human tissues and cell types, to produce an atlas of active, in vivo-transcribed enhancers. We...
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