Article

Tissue specific LRRK2 interactomes reveal a distinct functional unit within the striatum

2022-06-28

Abstract excerpt

Mutations in LRRK2 are the most common genetic cause of Parkinson’s disease. Despite substantial research efforts, the physiological and pathological role of this multidomain protein remains poorly defined. In this study, we used a systematic approach to construct the general protein-protein interactome around LRRK2, which was then differentiated into 15 tissue-specific interactomes taking into consideration the...

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Literature Corpus work: 39b3d589-c569-520c-aa96-70baa6d488e3
DOI: 10.1101/2022.06.28.497918

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