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Transcriptomics and weighted protein network analysis of the LRRK2 protein interactome reveal distinct molecular signatures for sporadic and LRRK2 Parkinson’s Disease

2023-09-13

Abstract excerpt

Mutations in the LRRK2 gene are the most common genetic cause for familial Parkinson’s Disease (LRRK2-PD) and an important risk factor for sporadic PD (sPD). Multiple clinical trials are ongoing to evaluate the benefits associated with the therapeutical reduction of LRRK2 kinase activity. In this study, we described the changes on transcriptomic profiles (whole blood mRNA levels) of LRRK2 protein interactors in th...

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Literature Corpus work: f8f3c76b-ff24-5d99-bda9-ab972ee2254c
DOI: 10.1101/2023.09.12.557373

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