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Article

In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung.

Brain research - 15 Aug 2021

Verma Amrita, Ebanks Kirsten, Fok Chi-Yee, Lewis Patrick A, Bettencourt Conceicao, Bandopadhyay Rina

Abstract excerpt

Mutations in LRRK2 are the most frequent cause of familial Parkinson's disease (PD), with common LRRK2 non-coding variants also acting as risk factors for idiopathic PD. Currently, therapeutic agents targeting LRRK2 are undergoing advanced clinical trials in humans, however, it is important to understand the wider implications of LRRK2 targeted treatments given that LRRK2 is expressed in diverse tissues including...

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Identifiers

PMID: 33915162
DOI: 10.1016/j.brainres.2021.147503
PMCID: PMC8212912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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