Article
LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights.
Cells - 5 Jan 2022
Skelton Patrick D, Tokars Valerie, Parisiadou Loukia
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease with a similar clinical presentation and progression to idiopathic Parkinson's disease, and common variation is linked to disease risk. Recapitulation of the genotype in rodent models causes abnormal dopamine release and...
Topics
- Amino Acid Sequence
- Animals
- Corpus Striatum
- Disease Models, Animal
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Models, Biological
- Mutation
- Synapses