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Article

LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights.

Cells - 5 Jan 2022

Skelton Patrick D, Tokars Valerie, Parisiadou Loukia

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease with a similar clinical presentation and progression to idiopathic Parkinson's disease, and common variation is linked to disease risk. Recapitulation of the genotype in rodent models causes abnormal dopamine release and increases the susceptibility of dopaminergic neurons to insults, making LRRK2 a valuable model for understanding the...

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Identifiers

PMID: 35011731
DOI: 10.3390/cells11010169
PMCID: PMC8750662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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