LRRK2 in Parkinson's disease: protein domains and functional insights.

doi:10.1016/j.tins.2006.03.006

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Article

LRRK2 in Parkinson's disease: protein domains and functional insights.

Trends in neurosciences - 1 May 2006

Mata Ignacio F, Wedemeyer William J, Farrer Matthew J, Taylor Julie P, Gallo Kathleen A

Abstract excerpt

Parkinson's disease (PD) is the most common motor neurodegenerative disease. Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) have been linked recently with autosomal-dominant parkinsonism that is clinically indistinguishable from typical, idiopathic, late-onset PD. Thus, the p...

Topics

Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Mutation
Parkinson Disease
Protein Serine-Threonine Kinases
Protein Structure, Tertiary

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