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Article

Tissue specific LRRK2 interactomes reveal a distinct striatal functional unit.

PLoS computational biology - 1 Jan 2023

Zhao Yibo, Vavouraki Nikoleta, Lovering Ruth C, Escott-Price Valentina, Harvey Kirsten, Lewis Patrick A, Manzoni Claudia

Abstract excerpt

Mutations in LRRK2 are the most common genetic cause of Parkinson's disease. Despite substantial research efforts, the physiological and pathological role of this multidomain protein remains poorly defined. In this study, we used a systematic approach to construct the general protein-protein interactome around LRRK2, which was then evaluated taking into consideration the differential expression patterns and the...

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Identifiers

PMID: 36716346
DOI: 10.1371/journal.pcbi.1010847
PMCID: PMC9910798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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