Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease.

doi:10.1002/jnr.21949

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Article

Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease.

Journal of neuroscience research - 1 May 2009

Gandhi Payal N, Chen Shu G, Wilson-Delfosse Amy L

Abstract excerpt

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, with a prevalence of more than 1% after the age of 65 years. Mutations in the gene encoding leucine-rich repeat kinase-2 (LRRK2) have recently been linked to autosomal dominant, late-onset PD that is clinically indis...

Topics

Animals
Brain
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Mutation
Parkinson Disease
Protein Serine-Threonine Kinases
RNA, Messenger
Signal Transduction

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