Article
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America - 18 Feb 2014
Beilina Alexandria, Rudenko Iakov N, Kaganovich Alice, Civiero Laura, Chau Hien, Kalia Suneil K, Kalia Lorraine V, Lobbestael Evy, Chia Ruth, Ndukwe Kelechi, Ding Jinhui, Nalls Mike A, Olszewski Maciej, Hauser David N, Kumaran Ravindran, Lozano Andres M, Baekelandt Veerle, Greene Lois E, Taymans Jean-Marc, Greggio Elisa, Cookson Mark R
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD), and common variants around LRRK2 are a risk factor for sporadic PD. Using protein-protein interaction arrays, we identified BCL2-associated athanogene 5, Rab7L1 (RAB7, member RAS oncogene family-like 1), and Cyclin-G-associated kinase as binding partners of LRRK2. The latter two genes are candidate genes for risk for...
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