Back to search

Article

ERAP2 protein allotypes show functional diversity in MHC-I antigen presentation in the human population

2026-01-24

Abstract excerpt

The Endoplasmic Reticulum AminoPeptidase 2 ( ERAP2 ) gene encodes an aminopeptidase involved in antigenic peptide processing for the MHC-I pathway. Genetic variants in the ERAP2 gene are associated with autoimmune conditions and infectious diseases. The linkage between genetic variants in the ERAP2 gene has given rise to the prevailing assumption that a single ERAP2 allotype with invariant amino acid sequence a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
398a93f7-89b7-572b-a765-c8cf61b7818b
DOI
10.64898/2026.01.22.26344601
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
ERAP2 protein allotypes show functional diversity in MHC-I antigen presentation in the human populationDOI 10.64898/2026.01.22.26344601
How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I ProteinsSemantic proximity
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.Semantic proximity
Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.Semantic proximity
A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.Semantic proximity
ERAP1 allotypes 2 and 10 differentially regulate the immunopeptidome of melanocytesSemantic proximity
Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection.Semantic proximity
ERAP1: a potential therapeutic target for a myriad of diseasesSemantic proximity
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: insights from genomic-wide association studies.Semantic proximity
An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes.Semantic proximity
Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1.Semantic proximity
Structural and biochemical insights into the association between ERAP1 polymorphism and autoimmune diseases.Semantic proximity
Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic propertiesSemantic proximity
Select a neighboring publication to make it the new centre.