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Article

ERAP1: a potential therapeutic target for a myriad of diseases

4 Apr 2020

Abstract excerpt

Introduction: Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key regulator of the peptide repertoire displayed by Major Histocompatibility Complex I (MHC I) to circulating CD8 + T cells and NK cells. Studies have highlighted the essential requirement for the generation of stable peptide MHC I in regulating both innate and adaptive immune responses in health and disease.Areas covered: We review the role of...

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PMID: 32249641
DOI: 10.1080/14728222.2020.1751821

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