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Article

Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Feb 2018

Hanson Aimee L, Cuddihy Thomas, Haynes Katelin, Loo Dorothy, Morton Craig J, Oppermann Udo, Leo Paul, Thomas Gethin P, Lê Cao Kim-Anh, Kenna Tony J, Brown Matthew A

Abstract excerpt

OBJECTIVE: Endoplasmic reticulum aminopeptidase 1 (ERAP-1) and ERAP-2, encoded on chromosome 5q15, trim endogenous peptides for HLA-mediated presentation to the immune system. Polymorphisms in ERAP1 and/or ERAP2 are strongly associated with several immune-mediated diseases with specific HLA backgrounds, implicating altered peptide handling and presentation as prerequisites for autoreactivity against an...

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Share to Aminopeptidases
Share to Chromosomes, Human, Pair 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Immune System Diseases

Share to Mass Spectrometry

Share to Minor Histocompatibility Antigens

Share to Sequence Analysis, RNA

Share to Spondylitis, Ankylosing

Source

Identifiers

PMID: 29108111
DOI: 10.1002/art.40369

Genes

ERAP1
ERAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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